Vocation; rush (6)
I believe the answer is:
career
<span class="explanation-format__ClueExplanation">I believe this is a double definition.<br/ ><br/ >'<span class="explanation-format__original">vocation</span>' is the first definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >'<span class="explanation-format__original">rush</span>' is the second definition.<br/ ><span class="explanation-format__explanation">(career can mean to run or move out of control)</span><br/ ><br/ ></span>
(Other definitions for career that I've seen before include "Lifetime occupation" , "Life (in terms of work etc)" , "Life's occupation" , "Run headlong at high speed" , "Run; calling" .)