1967 hit single by Marvin Gaye and Kim Weston (2,5,3)
I believe the answer is:
it takes two
(Other definitions for it takes two that I've seen before include "6 & 6 [ONE & ONE] are required in" , "Auntie's backstage gossip show!" , "Some things (such as a dance) you can't do by yourself!" .)
I've seen this clue in The Independent.
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