50% grey? That is female's misery (5)
I believe the answer is:
grief
'misery' is the definition.
(thesaurus)
'50 grey? that is female's' is the wordplay.
'50' means to take half the letters.
'that is' becomes 'ie' ('i.e.' can be a synonym of 'that is').
'female' becomes 'f' (abbreviation).
'grey' cut in half is 'gr'.
'gr'+'ie'+'f'='GRIEF'
(Other definitions for grief that I've seen before include "Deep sorrow" , "Anguish" , "Suffering" , "sad state" , "Misery" .)