50 inch thread (5)
I believe the answer is:
lisle
'thread' is the definition.
(I know that lisle is a type of cotton)
'50 inch' is the wordplay.
'50' becomes 'l' (Roman numeral).
'inch' becomes 'isle' (I've seen this before).
'l'+'isle'='LISLE'
(Other definitions for lisle that I've seen before include "Fine cotton thread used in stockings" , "Strong cotton fabric" , "Strong cotton material" , "Cotton stocking thread" , "Fine smooth cotton thread for stockings" .)