A Bandon optimism in Depression (7)
I believe the answer is:
despair
'depression' is the definition.
(thesaurus)
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for despair that I've seen before include "gloom" , "Feeling of hopelessness" , "The feeling that nothing will turn out well" , "Opposite of 10" , "sort of counsel?" .)