A chamber in space (4)
I believe the answer is:
room
This clue is a double definition.
'a chamber' is the first definition.
(I know that chamber can be written as room)
'space' is the second definition.
(enough space or room to do something)
'in' acts as a link.
(Other definitions for room that I've seen before include "Place" , "Space; part of building" , "Chamber; scope" , "Enclosed part of building" , "Space, area" .)