A course on holiday (4)
I believe the answer is:
away
'on holiday' is the definition.
(away from one's home)
'a course' is the wordplay.
'course' becomes 'way' (way is a kind of course).
'a'+'way'='AWAY'
(Other definitions for away that I've seen before include "Non-home match" , "Missing" , "playing at United?" , "Game played at opponents' ground" , "At a distance; match" .)