A cross is in line (4)
I believe the answer is:
axis
'line' is the definition.
(axis is a kind of line)
'a cross is' is the wordplay.
'cross' becomes 'x'.
'a'+'x'+'is'='AXIS'
'in' acts as a link.
(Other definitions for axis that I've seen before include "Line from N. to S. Pole" , "Turning point" , "Line around which something rotates" , "Pivot, political alliance" , "Line of symmetry" .)