Crossword Genius

A difference with one's spouse? (3)

Ross

I believe the answer is:

sex

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This could be a double definition.

'a difference' is the first definition.
The definition and answer can be both human attributes as well as being singular nouns.
Perhaps they are linked in a way I don't understand?

'one's spouse?' is the second definition.
Although both the answer and definition are singular nouns, I don't see how one could define the other.

'with' is the link.

Can you help me to learn more?

(Other definitions for sex that I've seen before include "Hanky-panky" , "This symbol is epitome of glamour" , "Expert in the treatment of coital problems" , "VI (Lat.); m. or f." , "Male or female" .)

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