A drug smuggler with time and charm (6)
I believe the answer is:
amulet
'charm' is the definition.
(amulet is a kind of charm)
'a drug smuggler with time' is the wordplay.
'drug smuggler' becomes 'mule' (I've seen this before).
'with' means one lot of letters go next to another.
'time' becomes 't'.
'a'+'mule'+'t'='AMULET'
'and' acts as a link.
(Other definitions for amulet that I've seen before include "Protective jewellery" , "Charm worn against bad luck" , "Ornament thought to give protection" , "Protective trinket" , "lucky defender" .)