A grand musical work takes time (5)
I believe the answer is:
opera
'a grand musical' is the definition.
'opera' can be an answer for 'musical' (I've seen this before). I am not sure about the 'a grand' bit.
'work takes time' is the wordplay.
'work' becomes 'op' (abbreviation for opus).
'takes' is a charade indicator (letters next to each other).
'time' becomes 'era' (an era is a period of time).
'op'+'era'='OPERA'
Can you help me to learn more?
(Other definitions for opera that I've seen before include "Die Meistersinger is one" , ""The Magic Flute", for example" , "Music and drama production" , "Musical 11 across" , "Grand or comic work?" .)