A grass runs wild, problem growth in the main (9)
I believe the answer is:
sargassum
'growth in the main' is the definition.
Although both the answer and definition are singular nouns, I cannot see how they can define each other.
'a grass runs wild problem' is the wordplay.
'runs wild' indicates an anagram.
'problem' becomes 'sum' (arithmetic problem).
'a'+'grass'='agrass'
'agrass' anagrammed gives 'sargas'.
'sargas'+'sum'='SARGASSUM'
Can you help me to learn more?
(Another definition for sargassum that I've seen is " seaweed".)