A guest’s complaint? (4)
I believe the answer is:
ague
'complaint?' is the definition.
(ague is a kind of disease)
'a guest's' is the wordplay.
'guest's' becomes 'gue' (I can't justify this - if you can you should believe this answer much more).
'a'+'gue'='AGUE'
(Other definitions for ague that I've seen before include "Acute fever; shivering fit" , "Fit of shivering and shaking" , "nasty illness?" , "Fever (archaic)" , "Malarial fever or fit of shivering" .)