A high-pitched reaction to last of the reds coming in contact off white? (6)
I believe the answer is:
scream
'contact off white?' is the definition.
The answer and definition can be both related to communication as well as being singular nouns.
Maybe you can see an association between them that I can't see?
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for scream that I've seen before include "Holler" , "Yell in fear" , "Scar me (anag)" , "A shrill yell as from fright" , "Yell for creams" .)