A large quantity of flotsam (3)
I believe the answer is:
lot
'a large quantity' is the definition.
(I've seen this before)
'of flotsam' is the wordplay.
'of' indicates the answer is hidden within the clue.
'LOT' is hidden within 'flotsam'.
(Other definitions for lot that I've seen before include "A person's luck" , "Kismet" , "biblical refugee" , "part of France?" , "one whose wife was backward-looking?" .)