A-lister making a comeback? Botheration! (4)
I believe the answer is:
rats
'a-lister making a comeback? botheration' is the definition.
I can't tell whether this definition defines the answer.
'a-lister making a comeback?' is the wordplay.
'a-lister' becomes 'star' (both can mean someone famous).
'making a comeback?' is a reversal indicator.
'star' backwards is 'RATS'.
Can you help me to learn more?
(Other definitions for rats that I've seen before include "Blast" , "Heels" , "First word of 'The 21 19'" , "Tells" , "Annoyed expression" .)