A little room, initially far distant (5)
I believe the answer is:
aloof
'distant' is the definition.
(synonyms)
'a little room initially far' is the wordplay.
'little room' becomes 'loo' (lavatories are typically small rooms).
'initially' says to take the initial letters.
The first letter of 'far' is 'f'.
'a'+'loo'+'f'='ALOOF'
(Other definitions for aloof that I've seen before include "Indifferent - by oneself" , "Withdrawn, supercilious" , "reserved" , "Snooty" , "rather cold" .)