A lot of activity to make wine (4)
I believe the answer is:
asti
'wine' is the definition.
(Italian wine)
'a lot of activity' is the wordplay.
'lot of' means to remove the last letter (I've seen 'lots of' mean this (the majority of the word)).
'activity' becomes 'stir' (I've seen this in another clue).
'stir' with its last letter taken away is 'sti'.
'a'+'sti'='ASTI'
'to make' acts as a link.
(Other definitions for asti that I've seen before include "Bubbly wine" , "Sparkling drink" , "town in Italy" , "White wine named after a town in Piedmont" , "Fizzy wine" .)