A man with a mother (4)
I believe the answer is:
adam
'a man' is the definition.
(Adam is an example)
'with a mother' is the wordplay.
'with' means one lot of letters go next to another.
'mother' becomes 'dam' (female parent of an animal).
'a' next to 'dam' is 'ADAM'.
(Other definitions for adam that I've seen before include "first in the race?" , "Biblical first man" , "A mad sort of ancestor" , "The first known ancestor" , "Robert -, Sc. architect" .)