A musical group on leave (7)
I believe the answer is:
abandon
'leave' is the definition.
(to abandon is to leave or desert)
'a musical group on' is the wordplay.
'musical group' becomes 'band' (band is a kind of musical group).
'a'+'band'+'on'='ABANDON'
(Other definitions for abandon that I've seen before include "Cast aside" , "Desert; lack of restraint" , "Desert, strand" , "Completely give up; desert" , "Jack in" .)