A negative in some trouble (5)
I believe the answer is:
annoy
'trouble' is the definition.
(I've seen this in another clue)
'a negative in some' is the wordplay.
'a negative' becomes 'no' (no is a kind of negative).
'in' is an insertion indicator.
'some' becomes 'any' (similar in meaning).
'no' inserted inside 'any' is 'ANNOY'.
(Other definitions for annoy that I've seen before include "be a nuisance" , "Make slightly angry" , "Irritate, nettle" , "Irk" , "Upset" .)