A nice change to be with an Eastern relative (5)
I believe the answer is:
niece
'relative' is the definition.
(type of relative)
'a nice change to be with an eastern' is the wordplay.
'change' indicates an anagram.
'to be with' means one lot of letters go next to another.
'an eastern' becomes 'e'.
'nice' anagrammed gives 'niec'.
'niec'+'e'='NIECE'
(Other definitions for niece that I've seen before include "A younger female relative" , "A sibling's child" , "girl further down the line" , "Brother or sister's daughter" , "One of the family" .)