A novel once more (4)
I believe the answer is:
anew
'once more' is the definition.
(I've seen this in another clue)
'a novel' is the wordplay.
'novel' becomes 'new' (novel means new or fresh).
'a'+'new'='ANEW'
(Other definitions for anew that I've seen before include "From the beginning again" , "Again but differently" , "Afresh" , "Wane in a different way, again" , "Once more (poetic)" .)