A peculiar match abandoned with reference to drugs (14)
I believe the answer is:
pharmaceutical
'with reference to drugs' is the definition.
(as in pharmacy)
'a peculiar match abandoned' is the wordplay.
'abandoned' is an anagram indicator (the original order is abandoned).
'a'+'peculiar'+'match'='apeculiarmatch'
'apeculiarmatch' is an anagram of 'PHARMACEUTICAL'.
(Other definitions for pharmaceutical that I've seen before include "Medicinal drug" , "involving drugs" , "Relating to medicinal drugs" , "Relating to prescribed drugs" .)