A refusal to give a home to one boy (6)
I believe the answer is:
denial
'a refusal' is the definition.
(I've seen this before)
'give a home to one boy' is the wordplay.
'give' means one lot of letters go next to another.
'a home' becomes 'den' (I've seen this before).
'to one' becomes 'i' (roman numeral).
'boy' becomes 'al'.
'den'+'i' is 'deni'.
'deni'+'al'='DENIAL'
'to' acts as a link.
(Other definitions for denial that I've seen before include "Nailed (anag.)" , "Daniel (anag.)" , "Rejection or refusal" , "Saying it isn't so" , "Negation" .)