A route not taken by many across the pond? (6)
I believe the answer is:
abroad
'across the pond?' is the definition.
(across the pond means in America)
'a route not taken by many' is the wordplay.
'route not taken by many' becomes 'B road' (a B-road is a minor road).
'a'+'broad'='ABROAD'
(Other definitions for abroad that I've seen before include "At large; widely current" , "Europe, for example" , "over a wide area" , "Away from home" , "In foreign land" .)