A series of Holbein paintings makes one feel severely uncomfortable (2,2,4)

'severely uncomfortable' is the definition.
I can't judge whether this definition defines the answer.

'a series of holbein paintings makes one feel' is the wordplay.
I cannot quite understand how this works, but
'a' is present in the answer.
'one' could be 'i' (Roman numeral) and 'i' is located in the answer.
'feel' could be 'be' and 'be' is present in the answer.
This may be the basis of clue (or it may be nonsense).

Can you help me to learn more?