A sign Alec's tinkered with opiate maybe (9)
I believe the answer is:
analgesic
'opiate maybe' is the definition.
I can't tell whether this definition defines the answer.
'a sign alec's tinkered with' is the wordplay.
'tinkered with' indicates anagramming the letters.
'sign'+'alec'='signalec'
'signalec' anagrammed gives 'nalgesic'.
'a'+'nalgesic'='ANALGESIC'
Can you help me to learn more?
(Other definitions for analgesic that I've seen before include "A medicine used to relieve pain" , "Pain reliever" , "Acting to relieve pain" , "Relieving pain" , "medicament" .)