A sign differs very largely (5)
I believe the answer is:
aries
'a sign' is the definition.
(star sign)
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for aries that I've seen before include "Philip -, English poet" , "A sign from Heaven" , "star group" , "Zodiacal sign also known as the Ram" , "Stars" .)