A slip leads to a horror striking the head (5)
I believe the answer is:
error
'a slip' is the definition.
(slip can mean an error or mistake)
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for error that I've seen before include "Miscarriage of justice" , "A mistake or inaccuracy" , "Slip-up" , "Gaffe" , "Miscalculation" .)