A way man gets lost (6)
I believe the answer is:
astray
'lost' is the definition.
(synonyms)
'a way man' is the wordplay.
'way' becomes 'st' (abbreviation for street).
'man' becomes 'ray' (Man Ray was a 20th-century artist).
'a'+'st'+'ray'='ASTRAY'
'gets' acts as a link.
(Other definitions for astray that I've seen before include "in the wrong place" , "Going wrong" , "A satyr (anag.)" , "wide of the mark" , "Wandering, off course" .)