A wicket with line wrong (4)
I believe the answer is:
awry
'wrong' is the definition.
(synonyms)
'a wicket with line' is the wordplay.
'wicket' becomes 'w'.
'with' is a charade indicator (letters next to each other).
'line' becomes 'ry' (abbreviation for railway).
'a'+'w'+'ry'='AWRY'
(Other definitions for awry that I've seen before include "Distorted, crooked" , "oblique" , "Amiss - distorted" , "being on the wrong course" , "Crooked, twisted to one side" .)