A young lady is wrong (5)
I believe the answer is:
amiss
'is wrong' is the definition.
(synonyms)
'a young lady' is the wordplay.
'young lady' becomes 'miss' (term of address for a young woman).
'a'+'miss'='AMISS'
(Other definitions for amiss that I've seen before include "Mistaken" , "Haywire" , "Wrong; inaccurate" , "inappropriately" , "Mistakenly" .)