Abandonment of rule in mine is producing chest disease (9)

'chest disease' is the definition.
I don't know anything about this answer so I can't judge whether this works.

'abandonment of rule in mine is' is the wordplay.
'abandonment of' indicates an anagram.
'in' means one lot of letters goes inside another.
'mine' becomes 'pit' (down the pit).
'rule' is an anagram of 'leur'.
'leur' put into 'pit' is 'pleurit'.
'pleurit'+'is'='PLEURITIS'

'producing' acts as a link.

Can you help me to learn more?