Abraham ties me in knots (6)
I believe the answer is:
semite
'abraham' is the definition.
(the biblical Abraham is a Semite)
'ties me in knots' is the wordplay.
'in knots' indicates an anagram (I've seen this in other clues).
'ties'+'me'='tiesme'
'tiesme' is an anagram of 'SEMITE'.
(Other definitions for semite that I've seen before include "one with Jewish blood" , "Arab maybe" , "Jew or Arab" , "Member of a group of peoples of the Middle East and northern Africa" , "Member of Jewish or Arab race" .)