Accuse falsely, according to some heartlessly (7)
I believe the answer is:
asperse
'accuse falsely' is the definition.
(I've seen this before)
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for asperse that I've seen before include "Slander or calumniate" , "Spares E. only to slander him" , "See spar could slander oddly" , "Call names" , "Defame" .)