Ace getting cheeky again? (6)
I believe the answer is:
afresh
'again?' is the definition.
(synonyms)
'ace getting cheeky' is the wordplay.
'ace' becomes 'a' (abbreviation).
'getting' is a charade indicator (letters next to each other).
'cheeky' becomes 'fresh' (I've seen this before).
'a'+'fresh'='AFRESH'
(Other definitions for afresh that I've seen before include "Academy award" , "In a different way" , "Anew, from the beginning" , "In a new way" , "Newly" .)