Actress Dern (5)
I believe the answer is:
laura
'actress dern' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for laura that I've seen before include "1944 American film noir directed by Otto Preminger" , "US First Lady" , "- Ashley, Welsh clothing and furniture designer" , "- Ashley, Welsh clothes, furnishings designer" , "girl" .)