Actually at home, female needs to do something (2,4)
I believe the answer is:
in fact
'actually' is the definition.
('in fact' can be a synonym of 'actually')
'home female needs to do something' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'female' becomes 'f' (abbreviation).
'needs' is a charade indicator (letters next to each other).
'to do something' becomes 'act' ('act' can be a synonym of 'do something').
'in'+'f'+'act'='IN FACT'
'at' is the link.
(Other definitions for in fact that I've seen before include "'In reality (2,4)'" , "Actually" , "really!" .)