Admire son probing setback (7)
I believe the answer is:
reverse
'setback' is the definition.
(synonyms)
'admire son probing' is the wordplay.
'admire' becomes 'revere' (I've seen this in another clue).
'son' becomes 's' (genealogical abbreviation for son).
'probing' is an insertion indicator (probe can mean to make a hole in).
'revere' enclosing 's' is 'REVERSE'.
(Other definitions for reverse that I've seen before include "Countermand" , "Invert" , "come back" , "Back (of a coin or medal)" , "Go in the opposite direction" .)