Adventure holiday coming up in Madeira, fascinating (6)
I believe the answer is:
safari
'adventure holiday' is the definition.
'coming up in madeira fascinating' is the wordplay.
'coming up' shows that the letters should be reversed in order.
'in' indicates a hidden word.
'irafas' is hidden within 'madeira fascinating'.
'irafas' reversed gives 'SAFARI'.
(Other definitions for safari that I've seen before include "Expedition to look at wildlife" , "Big game expedition" , "Animal expedition" , "Long expedition" , "Expedition to see animals" .)