Affair in Sons and Daughters (5)
I believe the answer is:
issue
This clue is a triple definition!
'affair' is the first definition.
(thesaurus)
'in' acts as a link.
'sons' is the second definition.
(thesaurus)
'and' is a link.
'daughters' is the third definition.
(thesaurus)
(Other definitions for issue that I've seen before include "Come forth or bring out" , "Argument" , "particular edition of magazine?" , "Progeny of, send out" , "Result, outcome; topic" .)