African river with nothing English (4)
I believe the answer is:
nile
'african river' is the definition.
(I've seen this before)
'with nothing english' is the wordplay.
'with' is a charade indicator (letters next to each other).
'nothing' becomes 'nil' (eg nil is zero in football).
'english' becomes 'E' (abbreviation).
'nil' put next to 'e' is 'NILE'.
(Other definitions for nile that I've seen before include "River that's Blue and White" , "Green" , "Take a line to the river" , "Current" , "Cleopatra's river" .)