After 50, single lady losing heart … may feel this? (6)
I believe the answer is:
lonely
'feel this?' is the definition.
The definition suggests a singular noun but the answer is not.
'after 50 single lady losing heart' is the wordplay.
'after' is a charade indicator (letters next to each other).
'50' becomes 'l' ('L' can be a synonym of '50').
'single' becomes 'one' (I've seen this before).
'losing heart' says to hollow out the word (remove centre letters).
'lady' with its middle removed is 'ly'.
'l'+'one' is 'lone'.
'lone'+'ly'='LONELY'
'may' is the link.
(Other definitions for lonely that I've seen before include "'I wandered ..... as a cloud' Wordsworth )" , "Solitary and sad" , "Forlorn, solitary" , "without friends" , "From the beginning (Latin)" .)