After extremes of bother, Edna upsets her (6)
I believe the answer is:
brenda
'her' is the definition.
'after extremes of bother edna upsets' is the wordplay.
'after' says to put letters next to each other.
'extremes of' says to hollow out the word (remove centre letters) (only the letters at the extremes of the word).
'upsets' is an anagram indicator.
'bother' with its middle removed is 'br'.
'edna' anagrammed gives 'enda'.
'br' put next to 'enda' is 'BRENDA'.
(Another definition for brenda that I've seen is " - - Blethyn, actress".)
I've seen this clue in the Evening Standard.
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