After holiday took meal, being empty (6)
I believe the answer is:
vacate
'being empty' is the definition.
(I've seen this before)
'after holiday took meal' is the wordplay.
'after' is a charade indicator (letters next to each other).
'holiday' becomes 'vac' (abbreviation for vacation).
'took meal' becomes 'ate' (ate a meal).
'vac'+'ate' is 'VACATE'.
(Other definitions for vacate that I've seen before include "Clear out and leave empty" , "Depart from, leave empty" , "Quit" , "Withdraw as from premises" , "Leave (a position)" .)