After taking ecstasy she appeared strangely bottom heavy (4-6)
I believe the answer is:
pear-shaped
'bottom heavy' is the definition.
The definition suggests an adjective which matches the answer.
'after taking ecstasy she appeared strangely' is the wordplay.
'after taking' indicates named letters should be taken away.
'ecstasy' becomes 'E' (informal term for the drug).
'strangely' indicates anagramming the letters.
'she'+'appeared'='sheappeared'
'sheappeared' with 'e' taken away is 'shappeared'.
'shappeared' is an anagram of 'PEAR-SHAPED'.
Can you help me to learn more?
(Other definitions for pear-shaped that I've seen before include "With hips very wide compared to the upper body" , "Bottom-heavy: (gone) wrong" , "Fat at one end and thin at the other - all wrong!" , "(Go) horribly wrong; like three Satie pieces" .)