After that comes the end of Autumn (4)
I believe the answer is:
then
'after that' is the definition.
(synonyms)
'the end of autumn' is the wordplay.
'end of' says to take the final letters.
The final letter of 'autumn' is 'n'.
'the'+'n'='THEN'
'comes' is the link.
(Other definitions for then that I've seen before include "Afterwards - as a result" , "Subsequently - previously" , "Once upon a time" , "soon?" , "Consequently" .)