Again arrange holiday location (6)
I believe the answer is:
resort
'holiday location' is the definition.
(I've seen this before)
'again arrange' is the wordplay.
'again' becomes 're' (prefix meaning 'again').
'arrange' becomes 'sort' (I've seen this before).
're'+'sort'='RESORT'
(Other definitions for resort that I've seen before include "Spa perhaps" , "Holiday town" , "place for holidaymakers to go to" , "Frequently visited place" , "Place for holidays" .)