Again can take one different ways (4)
I believe the answer is:
anew
'again' is the definition.
(synonyms)
'one different ways' is the wordplay.
'one' becomes 'an' (I've seen this in other clues).
'different ways' becomes 'ew' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'an'+'ew'='ANEW'
'can take' acts as a link.
This may not be right. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for anew that I've seen before include "Again but differently" , "Once more (poetic)" , "Afresh" , "Wane in a different way, again" , "From the beginning again" .)